Melanotan II (MT2 or MT-II) is a synthetic melanocortin receptor agonist peptide. It is an artificial analog of natural alpha-melanocyte-stimulating hormone ( -MSH), with the molecular formula C50H69N15O9 and a molecular weight of approximately 1024.18. Its peptide sequence contains seven amino acids and a cyclic structure composed of amide bonds, giving it strong stability. The MT2 peptide can interact with melanocortin receptors (such as MC1R, MC3R, and MC4R) in the body and is often used in scientific research to explore physiological mechanisms such as pigmentation, appetite regulation, metabolic homeostasis, and sexual function.
The MT2 peptide was initially developed by a research team at the University of Arizona College of Medicine with the initial goal of preventing skin cancer. Researchers discovered that this compound can effectively stimulate melanocytes to produce melanin without excessive sun exposure, thereby enhancing the skin's UV protection ability. As research progresses, scientists have discovered that MT2 peptide, in addition to promoting tanning, can also activate melanocortin receptors in the central nervous system, producing various physiological responses such as appetite suppression and enhanced sexual arousal. Currently, MT2 peptide is mainly sold globally as a research reagent and catalog peptide. Related clinical studies are still being conducted in strictly controlled laboratory environments to further evaluate its long-term safety and potential therapeutic applications.
1. Short-term use (within 1-2 months): Store in a sealed, light-protected container at 2℃-8℃, keeping it in a dry environment. Minimize opening the container to prevent moisture absorption and oxidation of the powder.
2. Long-term storage (more than 2 months): It is recommended to store in a sealed container at -20℃ to effectively protect the cyclic peptide chain structure, prevent peptide chain breakage and activity decay, and maintain product stability for a long time.
3. Do not store in an open container at room temperature, under direct sunlight, or in high-temperature and humid environments. Repeated freeze-thaw cycles are strictly prohibited to avoid structural damage and quality degradation.
Under standard storage conditions of complete sealing, protection from light, dryness, and stable temperature, this product has a shelf life of 24 months. If stored in a humid environment with large temperature fluctuations, or frequently opened and exposed to air, the powder will oxidize and degrade, directly shortening the product's lifespan and leading to unstable experimental data.
1. Stable Cyclic Structure and Strong Resistance to Degradation: MT2 is an artificially cyclized modified peptide. Compared to natural linear peptides, it exhibits significantly improved resistance to enzymatic hydrolysis and oxidation, is less prone to degradation and inactivation, has stronger structural stability, and a higher tolerance for experimental errors.
2. High-Purity Refined Product, Free of Impurities: Utilizing a multi-stage gradient purification process, it effectively removes synthetic residues, truncated peptides, byproducts, and other impurities. The standard output purity is >=98%, and customized high-purity (99%) is supported. Each batch is supported by HPLC and MS test data, ensuring verifiable quality.
3. Minimal Batch Variation and Excellent Experimental Reproducibility: Using standardized raw materials, synthesis parameters, purification procedures, and freeze-drying processes throughout the entire process, the purity, appearance, and solubility of each batch are strictly controlled, resulting in high batch consistency suitable for long-term comparative experiments and data review studies.
4. Rapid and thorough dissolution, suitable for various experimental systems: The lyophilized powder is loose and uniform with excellent hydrophilic properties. It dissolves well in pure water, buffer solutions, and DMSO, with rapid dissolution, no precipitation, and no floating impurities, making it suitable for various sophisticated scientific research experimental systems.
5. Ample stock and flexible supply: Mainstream specifications are kept in stock year-round, supporting small-sample testing, small-batch replenishment, and large-volume production orders. OEM packaging and private label customization services are available. Complete export documentation is provided, catering to domestic R&D and global trade procurement needs.
Strictly prohibited for human use: MT2 peptide is currently only for research use (For Research Use Only). It has not been approved by the FDA or other regulatory agencies for any human clinical treatment and is strictly prohibited for human injection or consumption.
Potential side effects: In animal and limited clinical trials, MT2 has been observed to cause side effects such as nausea, facial flushing, decreased appetite, and spontaneous erections. Furthermore, long-term use may lead to darkening and increase in the number of existing moles, and there is even a theoretical risk of inducing melanoma.
Contraindications: Individuals with a personal or family history of melanoma, atypical nevi, pregnant women, and breastfeeding mothers should strictly avoid or prohibit the use of this compound in research experiments.
Standardized Operation and Record Keeping: During laboratory handling, aseptic techniques must be followed. Properly record the compound's preparation, storage conditions, and animal experimental reactions. If severe adverse reactions occur (such as muscle pain, dark urine, or other signs of rhabdomyolysis), the experiment should be stopped immediately and reported.
Compliant Procurement: Due to the existence of unregulated products on the market, it is essential to choose reputable biological reagent suppliers that provide a Certificate of Analysis (COA) to ensure the purity and accurate concentration of the peptide.
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